27 set. trofoblástica gestacional; dois relataram mola hidatiforme completa, dois às evoluções da doença trofoblástica gestacional, cinco artigos. (2)Rio de Janeiro Trophoblastic Disease Center, Associação Brasileira de Doença Trofoblástica Gestacional, Rio de Janeiro, RJ, Brazil. RESUMO Doença trofoblástica gestacional inclui um grupo interrelacionado de doenças originadas do tecido placentário, com tendências distintas de invasão.

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Etiopathogenesis of hydatidiform mole Hydatidiform mole constitutes an error of fertilization. FIGO staging for gestational trophoblastic neoplasia Low risk of relapse after achieving undetectable HCG levels in women with partial molar pregnancy.

The role of surgery in the management of women with gestational trophoblastic disease.

Gadolinium contrast-enhanced MRI scan of the pelvis, showing, hypointense lesions with avid uptake and vascular dilation in the myometrium, sometimes in close contact with the uterine effusion, in patients treated for GTN.

When combined with Doppler flow studies, it is useful not only in the evaluation of GTN but also in the evaluation of the response to treatment and in the detection of GTN recurrence. Certain signs and symptoms of hydatidiform mole have become uncommon because the systematic use of ultrasound has resulted in the trofoblastca first-trimester detection of pregnancy.

Some cases of mole show nonspecific alterations on Doppler flow studies, although ultrasound is more widely used trofoblastiva the evaluation of cases of GTN 2, Anechoic spaces within the mass are related gestacionl hemorrhage, tissue necrosis, cysts, or vascular spaces 2, Fast MR imaging in obstetrics.

Complete hydatidiform mole originates from the fertilization of an oocyte without maternal chromosomes by a haploid sperm with subsequent duplication of paternal DNA, giving rise to tofoblastica egg of exclusively parthenogenetic origin, with a diploid 46,XX karyotype.

It is superior to ultrasound in identifying parametrial and vaginal invasion 2. How to cite this article. Human chorionic gonadotropin follow-up in patients with molar pregnancy: Current management of gestational trophoblastic diseases.

Gillespie AM, et al. Pelvic ultrasound showing a massive theca lutein cyst in a patient with complete hydatidiform mole. Another use of conventional angiography is in the management of cases of uterine arteriovenous malformations after GTN in patients who are symptomatic and wish to conceive, given that selective embolization of such malformations, via the uterine artery, has provided auspicious results.


In this review, we present clinical and radiological correlations in patients with GTD, describing the diagnostic requirements for the use of the various ancillary methods, together with details regarding their radiological aspects and therapeutic utility donea GTD, as well as summarily updating the information about this important complication of pregnancy.

Masselli G, Gualdi G. Because PSTT and ETT respond poorly to chemotherapy, they should be treated with chemotherapy and hysterectomy, sometimes including pelvic lymphadenectomy Accepted after revision September 9, These changes have also been identified in routine cases of miscarriage and in patients who have recently undergone doeba.

MOLA HIDATIFORME. – ppt video online carregar

On ultrasound imaging, it can be difficult to differentiate between complete and partial hydatidiform moles. Gestational trophoblastic disease I: There is no evident vascularization In rare cases, there is adnexal torsion with acute vascular abdomen or rupture that results in hemoperitoneum, both of which call for immediate treatment Vascular malformations can be detected years after treatment 2.

Although of limited clinical significance, micrometastases can be seen scattered diffusely throughout the lung parenchyma. Hydropic degeneration of the placenta, which occurs in some cases of abortion, produces images of the placenta similar to those seen in cases of partial hydatidiform mole, thus increasing the difficulty of making the diagnosis with ultrasound 3.

Through the use of MRI, the location, vasculature, and extent of the tumor can be evaluated with greater accuracy. Current management of gestational trophoblastic neoplasia.

Note the presence of hypoechoic areas in the myometrium, resembling the hypervascular “Swiss cheese” aspect, suggestive of an invasive mole, on the Doppler flow study. Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease: Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region. Surgery and radiotherapy are necessary in some patients with high-risk GTN, especially in those with chemoresistance.


N Engl J Med. In such cases, partial hydatidiform mole with trisomy is differentiated by identifying a separate, normal, placenta 1,2, There are three basic forms of radiological presentation of metastatic pulmonary GTN: One of the most common treatment regimens is the combination of etoposide, methotrexate, and actinomycin-D, alternating weekly with cyclophosphamide plus vincristine In such cases, ultrasound is mandatory in order to exclude this form of reproductive counterfeiting It is usually accompanied by malformation of the gestational sac or of the fetus, which can have characteristics such as hydrocephalus, syndactyly, cleft lip, and growth restriction Myometrial invasion can be suspected when the lesion crosses the myoendometrial border and the transitional zone becomes undefined.

From the archives of the AFIP. Gestational trophoblastic disease II: Hashem E, Hassan M.

Rev Trofoblasgica Ginecol Obstet. Other conditions can have a similar appearance, such conditions including the presence trfoblastica residual trophoblastic tissue from a miscarriage or ectopic pregnancy, pelvic inflammatory disease, other uterine malignancies, diverticulitis or appendicitis with uterine abscesses, and uterine arteriovenous malformations Ultrasound in GTN Myometrial invasion is best defined by transvaginal ultrasound.

In the hypervascular form, the tumor has an isointense signal on T1-weighted images, a slightly hyperintense signal on T2-weighted images, and avid uptake after the administration of contrast gadolinium. Modares M, et al. At some facilities, despite the superiority of transvaginal imaging, pre-chemotherapy molar pregnancy patients often do not undergo transvaginal ultrasound gesfacional to the chance that a vaginal metastasis, which has a risk of major bleeding 2will be encountered.

The typical image is that of dense nodules with well-defined contours, usually multiple and bilateral Figure 7.