Klucel™ LF Pharma, SDS · TDS*. Klucel™ M CS, Klucel™ M CS has excellent film-forming properties and thickens non-aqueous systems and provide lubricious. Klucel hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release, and film coating. This unique polymer. Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with Klucel HPC is soluble in many polar organic solvents and in water below.
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HPC polymers are non-ionic hydrophilic polymers that undergo polymer-chain-length-dependent solubilization and can be used to enhance solubility or dissolution rate of poorly soluble drugs. Compressibility profiles did not exhibit any difference among extruded formulations. They were stored in nitrogen-filled plastic bags in a refrigerator until further evaluation. Earlier studies performed on HPC HF, a higher molecular weight grade of HPC, report the advantages of using plasticizers and plasticizing effect of drugs Stability of such a system can be attributed to increased solid state solubility and hydrogen bond forming tendency of HPC Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction.
Hydroxypropylcellulose polymers undergo dissolution via a swelling- and erosion-driven mechanism which is dependent upon chain length The factors—increased surface area, amorphous form, and a hydrophilic matrix—contribute towards an increase in dissolution rate. BoxKeokuk, IA Solubility enhancement of poorly soluble drugs is an extensively researched area in the current pharmaceutical industry.
HPC is a long-chain, viscoelastic polymer that can expand or contract owing to flexibility of its polymer chains. A hot-stage microscope was used to replicate temperatures the material would be exposed to inside an extruder while polarized light microscope PLM was used to observe the changes in the material.
It was also observed that during extrusion process these formulations exhibited decreased die swelling. Extrudates pelletized and filled into capsules exhibited a carrier-dependent release with ELF polymer exhibiting a faster release.
Acknowledgments We would like to thank Mr. Ashland is a developer and manufacturer of stabilizers and gums used in the Food, Beverage, and Nutrition industry. Techniques such as solvent evaporation 2fusion method 34complexation, spray-drying 5and hot-melt extrusion 67 have been utilized to form solid dispersions, with spray-drying and hot-melt extrusion being the most widely utilized techniques 8.
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Control of the release of slightly water soluble medicine from solid dispersion granules. In formulations such as H4, infinite clusters or continuous phases are formed by soluble excipients HPC and MNTthereby decreasing tortuosity and increasing diffusivity of the dissolution media.
As per Higuchi matrix model, release from a matrix occurs by dissolution and diffusion of one component through the other Being a Biopharmaceutics Classification System Class II drug, dissolution is the rate-limiting step for absorption of orally administered KPR and hence was utilized as a model compound Scanning electron microscope SEM was used to study surface morphology of extruded pellets. Six replicates were tested. The peak of the plot can be used to calculate the distance travelled by the probe at the point of contact to the distance from the tablet surface to cause it to break.
Application of the solid dispersion method to the controlled release of medicine. Being a klucrl process, HME has significant utility in the manufacture of solid dispersions and solid solutions. However, such high energy forms tend to recrystallize or precipitate out from their supersaturated solutions. Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared kluvel hot melt extrusion. Six replicates were used for all the assay studies.
Many polymers have been evaluated for use in HME including hydroxypropylcellulose HPC 17polyvinyl pyrrolidone 18polyethylene oxide 19and sugars such as isomalt 20erythritol 21and mannitol This densification leads to a delayed disintegration kluceel also decreased surface area. HME exerts compression on molten material that results in densification and a subsequent decrease in porosity.
Increased temperatures and l of moisture enhances recrystallization and also degradation of drugs. It combines organic solvent solubility, thermoplasticity, and surface activity with the thickening and stabilizing properties of other water-soluble cellulose polymers.
Chem Pharm Bull Tokyo ; 41 2: These observations correlated with the data generated from compaction profiles. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films.
Compressibility, Compactibility, and Tabletability profiles as described by Tye et al. However, UL assumes no responsibility or liability for the accuracy of the information contained on this website and strongly encourages that upon final product or material selection information is validated with the manufacturer.
Also, the smaller chains in ELF might have contributed towards a lesser elastic recovery, and hence, no capping was observed at higher compaction pressures for un-extruded tablets TT andTT.
Klucel™ Hydroxypropylcellulose, Ashland – ChemPoint
Extrudates were prepared into pellets, to be directly filled into capsules or milled to be compressed into tablets. The process was optimized and extrudates evaluated for in vitro release, crystallinity, and surface morphology.
Higher molecular weight grades of Klucel polymers have been utilized earlier in kluce lab to kluce a similar carrier-dependent release True density measurements of the tabletting blends were performed using a Micromeritics helium pycnometer AccuPyc IICommunications Dr. Similar observations were made from polarized light microscope images of extruded systems. Tablet hardness evaluation—Extruded Vs Not-Extruded formulations.
In vitro release profiles tablets from extruded matrices. Extrudates were evaluated for any recrystallization that might have occurred at the end of storage time points.
HME also imparted physical properties to extruded systems that contributed toward better tabletting properties. It has been observed that such hydrophilic polymers solubilize at a faster rate leaving behind a super saturated drug in the media resulting in solution-mediated phase conversion Kluccel formulated from extrudate material were tested similarly.